December 13, 1993FEBS LettersOpen Access

The glycine residue of ATP regulatory module in receptor guanylate cyclases that is essential in natriuretic factor signaling

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Population

Receptor guanylate cyclases (ANF-RGC and CNP-RGC) studied via genetic remodeling techniques

Comparison

Genetic remodeling of ARM-Gly505 in ANF-RGC and… vs Other ARM-Gly residues

Design

Preclinical

Authors

TDTeresa DudaSalus University RGRafal GoraczniakRutgers, The State University of New Jersey RSRameshwar K. SharmaSalus University

Discussion

Member takes

Implication

Highlights potential targets for natriuretic peptide modulation; leaves open validation in human disease models.

Structured PICO

Population

Receptor guanylate cyclases (ANF-RGC and CNP-RGC) studied via genetic remodeling techniques

Intervention

Genetic remodeling of ARM-Gly505 in ANF-RGC and ARM-Gly499 in CNP-RGC

Comparator

Other ARM-Gly residues

Outcome

ANF and CNP signaling activationsurrogate

Identifies specific glycine residues in the ATP regulatory module of receptor guanylate cyclases that are essential for natriuretic peptide signaling.

Cite This Study

Duda et al. (1993) studied this question.

synapsesocial.com/papers/6a9080e7039ece43b30d5355 https://doi.org/10.1016/0014-5793(93)80408-m

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The glycine residue of ATP regulatory module in receptor guanylate cyclases that is essential in natriuretic factor signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The glycine residue of ATP regulatory module in receptor guanylate cyclases that is essential in natriuretic factor signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider