Key result
ATP dually regulates ANF-dependent guanylate cyclase, stimulating it with Mg2+ and inhibiting with Mn2+.
Why the study?
The regulation of atrial natriuretic factor-dependent guanylate cyclase activity by ATP and its cofactors was not fully understood.
Comparison
ATP stimulation versus inhibition of guanylate cyclase activity with Mg2+ or Mn2+ cofactors
Design
Biochemical study of testicular plasma membranes
Authors
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Extends ANF receptor regulation models; hypothesis-generating for physiological relevance and clinical translation.
Marala et al. (1991) conducted a review in Basic science (Guanylate cyclase signaling). ATP was evaluated. ATP dually regulates atrial natriuretic factor-dependent guanylate cyclase activity, stimulating it in the presence of Mg2+ and inhibiting it in the presence of Mn2+.
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