January 4, 1993FEBS Letters

Core sequence of ATP regulatory module in receptor guanylate cyclases

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Population

Receptor guanylate cyclases (ANF-RGC and CNP-RGC) studied via genetic remodeling techniques

Design

Preclinical

Authors

Discussion

Hypothesis-generating for natriuretic peptide receptor modulation; leaves open relevance to human cardiovascular signaling or therapy.

Population

Receptor guanylate cyclases (ANF-RGC and CNP-RGC) studied via genetic remodeling techniques

Intervention

Genetic remodeling to identify the core ATP-regulated module (ARM) sequence

Outcome

Identification of the core ARM sequence essential for ANF and CNP signalingsurrogate

Identified the core ATP-regulated module sequence (Gly-Xa-Xa-Xa-Gly) essential for ANF and CNP signaling in receptor guanylate cyclases.

Duda et al. (1993) studied this question.

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