Why the study?
Does pregnancy alter the excretion and ratio of aldosterone-18-glucuronide and tetrahydroaldosterone compared to nonpregnant women?
Does pregnancy alter the excretion and ratio of aldosterone-18-glucuronide and tetrahydroaldosterone compared to nonpregnant women?
Pregnancy is associated with increased formation of aldosterone-18-glucuronide, potentially reflecting greater availability of aldosterone for mineralocorticoid receptor interaction in the kidney.
Pregnancy-linked aldosterone metabolite shifts merit prospective evaluation; leaves open any role in gestational hypertension.
In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone metabolites was found. The Q-ratio (aldosterone-18-glucuronide/tetrahydro-aldosterone+aldosterone-18-glu cur onide) was also increased compared to healthy nonpregnant women. The elevated Q-ratios point out to increased formation of aldosterone-18-glucuronide. This predominantly renal metabolite may reflect greater availability of aldosterone molecules for interaction with mineralocorticoid receptor in the kidney.
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Wacker et al. (1995) studied this question.
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