March 1, 1990Development

Mutations affecting skeletal muscle myofibril structure in the zebrafish*

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Population

Zebrafish (Brachydanio rerio) embryos

Comparison

fub-l and fub-l mutations induced by… vs Wildtype zebrafish embryos

Design

Preclinical

Authors

AFAdam L. FelsenfeldNational Human Genome Research Institute CWCharline WalkerUniversity of Oregon MWMonte WesterfieldBrigham and Women's Hospital

Discussion

Member takes

Implication

Hypothesis-generating for myofibril assembly genes; leaves open translation to human congenital myopathies.

Structured PICO

Population

Zebrafish (Brachydanio rerio) embryos

Intervention

fub-l(b45) and fub-l(b126) mutations induced by gamma-irradiation

Comparator

Wildtype zebrafish embryos

Outcome

Organization of skeletal muscle myofibrils and embryonic viability

The study identifies a gene required for proper organization of skeletal muscle myofibrils in zebrafish, with mutations causing embryonic paralysis and disorganized myofibrils.

Cite This Study

Felsenfeld et al. (1990) studied this question.

synapsesocial.com/papers/6a887c5286ac178e8f609f93 https://doi.org/10.1242/dev.108.3.443

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