Why the study?
Does apocynin lower blood pressure and improve endothelial NO/superoxide balance in spontaneously hypertensive rats compared to nifedipine?
Does apocynin lower blood pressure and improve endothelial NO/superoxide balance in spontaneously hypertensive rats compared to nifedipine?
Apocynin effectively lowers blood pressure and improves endothelial function in a hypertensive rat model, suggesting potential as a novel antihypertensive therapy.
Apocynin merits further preclinical study in hypertension; leaves open translation to human therapy.
The vascular NAD(P)H oxidase contributes to endothelial dysfunction and high blood pressure in the spontaneously hypertensive rat by enhancing superoxide production. We investigated the effects of apocynin, a NAD(P)H oxidase inhibitor, on blood pressure and vascular radical and nitric oxide formation in SHR and compared its effects to the calcium channel blocker nifedipine. Apocynin (over four weeks) lowered systolic blood pressure significantly and as effectively as nifedipine. Both apocynin and nifedipine significantly reduced superoxide production. In parallel, vascular nitric oxide production and ecNOS activity was significantly increased by apocynin treatment. Therefore, apocynin may be an effective antihypertensive drug in essential hypertension.
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Bäumer et al. (2007) studied this question.
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