Increased ACE1/angII signaling causes aging-dependent, Aβ-accelerated selective hippocampal neuron vulnerability, suggesting brain-penetrant ACE inhibitors and AT1R blockers may protect against Alzheimer's disease.
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May warrant preclinical testing of brain-penetrant ACE inhibitors in Alzheimer's; leaves open human translation.
Cuddy et al. (2020) studied this question.
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