September 1, 1996Circulation
Intrinsic Tone as Potential Vascular Reserve in Conductance and Resistance Vessels
Population
Deendothelialized vascular preparations including ferret aorta, ferret pulmonary artery, human coronary…
Design
Preclinical
Authors
Discussion
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Implication
Intrinsic tone may underlie vasodilator-resistant resistance; animal data leave open its human relevance and targeting.
Structured PICO
P
Population
Deendothelialized vascular preparations including ferret aorta, ferret pulmonary artery, human coronary artery, ferret epicardial coronary artery, and ferret coronary microvessel
I
Intervention
Warming from 6 degrees C to 37 degrees C and application of various pharmacological agents (forskolin, milrinone, staurosporine, nitroprusside, adenosine, hydralazine, nifedipine)
O
Outcome
Degree of intrinsic tone (active increase in isometric force or decrease in vessel diameter)surrogate
Intrinsic tone represents a significant, calcium-independent component of vascular tone that is partially responsive to cAMP and PKC modulators but resistant to several common vasodilators.
Cite This Study
Jain et al. (1996) studied this question.