March 1, 1992The Journal of PhysiologyOpen Access

Mechanisms of intrinsic tone in ferret vascular smooth muscle.

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Population

Circular strips from ferret aorta

Comparison

Cooling, removal of extracellular Ca2+, removal… vs Baseline physiological conditions

Design

Preclinical

Authors

JPJohn E. PawlowskiFMC (United States)KMKathleen G. MorganVascular Medicine

Discussion

Member takes

Implication

Suggests distinct mechanisms for vascular stiffness and force; leaves open translation to human vasomotor disorders.

Structured PICO

Population

Circular strips from ferret aorta

Intervention

Cooling, removal of extracellular Ca2+, removal of endothelium, and staurosporine application

Comparator

Baseline physiological conditions

Outcome

Changes in stiffness, force, intracellular ionized Ca2+ concentrations, and myosin light chain phosphorylationsurrogate

Intrinsic basal tone in ferret aorta is maintained by mechanisms partially dependent on myosin light chain kinase and protein kinase C, but independent of extracellular calcium and the endothelium.

Cite This Study

Pawlowski et al. (1992) studied this question.

synapsesocial.com/papers/6a756dffe42ca79ec1e717c9 https://doi.org/10.1113/jphysiol.1992.sp019032

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Mechanisms of intrinsic tone in ferret vascular smooth muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of intrinsic tone in ferret vascular smooth muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider