What question did this study set out to answer?

To determine whether erythrocyte intracellular calcium concentration differs between spontaneously hypertensive rats and normotensive controls before and after calcium channel antagonist administration.

April 1, 1988Clinical and Experimental Pharmacology and Physiology

Red Blood Cell Ionized Calcium Concentration in Spontaneous Hypertension: Modulation in Vivo by the Calcium Antagonist Pn 200.110

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To determine whether erythrocyte intracellular calcium concentration differs between spontaneously hypertensive rats and normotensive controls before and after calcium channel antagonist administration.
Measured baseline red blood cell intracellular calcium concentration ([Ca2+]i) in conscious spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto controls (WKY).
Monitored blood pressure and erythrocyte [Ca2+]i at 5 minutes and 1 hour following in vivo administration of the dihydropyridine calcium antagonist PN 200.110.
Resting erythrocyte [Ca2+]i levels were qualitatively similar between SHR and WKY controls prior to drug intervention.
PN 200.110 administration induced a rapid decrease in blood pressure in both SHR and WKY rats without altering [Ca2+]i at 5 minutes.
At 1 hour post-injection, erythrocyte [Ca2+]i was significantly decreased in SHR, whereas no significant change was detected in WKY controls.

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Implication

Animal study reveals delayed reduction of erythrocyte calcium following calcium channel blockade in hypertensive rats, suggesting altered cellular calcium regulation.

Cite This Study

Morris et al. (1988) studied this question.

synapsesocial.com/papers/6a88edc7d5f4e697bb131346 https://doi.org/10.1111/j.1440-1681.1988.tb01068.x

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Implication

Animal study reveals delayed reduction of erythrocyte calcium following calcium channel blockade in hypertensive rats, suggesting altered cellular calcium regulation.

Red Blood Cell Ionized Calcium Concentration in Spontaneous Hypertension: Modulation in Vivo by the Calcium Antagonist Pn 200.110

Key Points

Discussion

Implication

Cite This Study

Red Blood Cell Ionized Calcium Concentration in Spontaneous Hypertension: Modulation in Vivo by the Calcium Antagonist Pn 200.110

Key Points

Discussion

Implication

Cite This Study

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