Why the study?
Does the insulin index derived from a 50-gm oral glucose tolerance test differentiate between normal subjects and patients with diabetes, thyroid disorders, or chronic hepatitis?
Does the insulin index derived from a 50-gm oral glucose tolerance test differentiate between normal subjects and patients with diabetes, thyroid disorders, or chronic hepatitis?
An insulin index derived from the linear relationship between serum insulin and glucose during an oral glucose tolerance test can distinguish diabetic and hyperthyroid patients from normal subjects and those with hypothyroidism or chronic hepatitis.
Answers are grounded in this paper and cite their sources.
May support differentiation of diabetes and hyperthyroidism; hypothesis-generating and requires prospective validation before clinical adoption.
When the serum insulin valves during a 50-gm oral glucose tolerance test were expressed as the function of glucose concentrations, a good linear relationship was found in normal subjects and in patients with diabetes, hyperthroidism, hypothroidism or chronic hepatitis. The insulin index calculated from the line representing this relationship was less than 100 in all 19 diabetic patients and most of the 13 hyperthyroid patients with oxyhyperglycemia, whereas it was more than 100 in the 14 normal subjects, the 4 hypothyroid patients, and the 8 patients with oxyhyperglycemia due to chronic hepatitis. The insulin index decreased with increasing maximal blood glucose concentration during the glucose tolerance test in diabetic patients. Furthermore, improvement in the insulin index was correlated with the effectiveness of sulfornylurea drugs in the diabetic group.
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Yamada et al. (1977) studied this question.
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