November 1, 1977Annals of Internal Medicine

Type III Hyperlipoproteinemia: Paradoxical Hypolipidemic Response to Estrogen

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Why the study?

Does ethinyl estradiol improve lipid profiles in patients with type III hyperlipoproteinemia?

Population

6 subjects with type III hyperlipoproteinemia on diets both of normal and of fat-free, high-carbohydrate…

Comparison

Ethinyl estradiol vs Estrogen withdrawal (baseline/off-treatment)

Design

Case_series

Authors

RKRampratap S. KushwahaTexas Biomedical Research Institute

Discussion

Member takes

Implication

Should not change practice in type III hyperlipoproteinemia; hypothesis-generating case observation requiring controlled trials.

Structured PICO

Does ethinyl estradiol improve lipid profiles in patients with type III hyperlipoproteinemia?

Population

6 subjects (5 women, 1 man) with type III hyperlipoproteinemia on diets both of normal and of fat-free, high-carbohydrate composition

Intervention

Ethinyl estradiol (1 microgram/kg body weight per day)

Comparator

Estrogen withdrawal (baseline/off-treatment)

Outcome

Hypolipidemic effect (very low-density lipoprotein lipid and apolipoprotein composition and electrophoretic mobility)surrogate

Ethinyl estradiol exerts a paradoxical hypolipidemic effect in patients with type III hyperlipoproteinemia, suggesting it facilitates the assimilation of chylomicron and VLDL remnants.

Cite This Study

Rampratap S. Kushwaha (1977) studied this question.

synapsesocial.com/papers/6a88f6a1e49c960f581fee62 https://doi.org/10.7326/0003-4819-87-5-517

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Type III Hyperlipoproteinemia: Paradoxical Hypolipidemic Response to Estrogen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Type III Hyperlipoproteinemia: Paradoxical Hypolipidemic Response to Estrogen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider