Why the study?
Does quinapril improve efficacy and safety compared to captopril in patients with moderate to severe or severe hypertension?
Does quinapril improve efficacy and safety compared to captopril in patients with moderate to severe or severe hypertension?
Quinapril is an effective and well-tolerated alternative to captopril for the treatment of moderate to severe hypertension, offering potentially better efficacy or more convenient dosing.
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Quinapril may offer better efficacy or convenience than captopril in hypertension; leaves open need for modern outcome trials.
Major studies comparing the efficacy and safety of quinapril and captopril in the treatment of moderate to severe or severe hypertension are reviewed. Given concurrently with hydrochlorothiazide 25 mg/day to patients with moderate to severe hypertension, quinapril 20-80 mg/day twice daily was found to be more effective than captopril 50-200 mg/day twice daily, and quinapril 10-40 mg/day once daily was found to be as effective as captopril 25-100 mg/day twice daily. Given as initial monotherapy to patients with severe hypertension, quinapril 10-40 mg/day twice daily was found to be as effective as captopril 50-200 mg/day twice daily. Quinapril was found to be well tolerated, both when administered against a diuretic background and when diuretic was added to a quinapril regimen.
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William H. Frishman (2009) studied this question.
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