September 1, 1981The Journal of General PhysiologyOpen Access

Nonlinear summation of contractions in cat muscles. I. Early depression.

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Population

Fast- and slow-twitch cat muscles

Comparison

Supramaximal electrical stimulation with various… vs Response to one pulse; baseline without Dantrolene

Design

Preclinical

Authors

RSR. B. SteinUniversity of Alberta FPF. ParmiggianiInstitute of Atmospheric Sciences and Climate

Discussion

Member takes

Implication

Animal data on twitch depression suggest saturable calcium mechanisms; leaves open translation to human neuromuscular physiology or therapy.

Structured PICO

Population

Fast- and slow-twitch cat muscles

Intervention

Supramaximal electrical stimulation with various numbers of pulses; Dantrolene administration

Comparator

Response to one pulse (twitch response); baseline without Dantrolene

Outcome

Force production and summation of contractionssurrogate

Repetitive stimulation of cat muscles leads to an early depression in contraction summation, likely mediated by saturable reactions such as calcium binding.

Cite This Study

Stein et al. (1981) studied this question.

synapsesocial.com/papers/6a88f765ab71709247a2a941 https://doi.org/10.1085/jgp.78.3.277

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Implication

Animal data on twitch depression suggest saturable calcium mechanisms; leaves open translation to human neuromuscular physiology or therapy.

Nonlinear summation of contractions in cat muscles. I. Early depression.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nonlinear summation of contractions in cat muscles. I. Early depression.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider