Why the study?
Telmisartan shows variable protective effects in cerebrocardiovascular trials, and its direct effects on endothelial functions, including NO production, vessel relaxation, and mechanisms of action, have not been fully elucidated.
Telmisartan inhibits endothelial nitric oxide production and vessel relaxation, providing a potential mechanistic explanation for its variable cerebrocardiovascular protective effects in clinical trials.
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May explain telmisartan's variable clinical effects; hypothesis-generating and requires human validation.
Du‐Hyong Cho (2019) studied this question.
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