Key result
Telmisartan inhibited vasoconstriction in mouse resistance arteries through a PPARγ-dependent increase in eNOS expression and activity, independent of AT1R blockade.
Population
Second-order mesenteric arteries isolated from male C57BL/6J, eNOS knockout, and PPARγ knockout mice
Comparison
Telmisartan vs Losartan, olmesartan, irbesartan, and untreated…
Design
Preclinical
Authors
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Hypothesis-generating for PPARγ-eNOS vasodilation by telmisartan in mice; leaves open human relevance and should not change practice.
Telmisartan exerts vasodilatory effects in resistance arteries via a PPARγ-dependent increase in eNOS activity, independent of its AT1 receptor blocking properties.
Yuen et al. (2010) studied this question. Telmisartan vs. Other ARBs (losartan, olmesartan, irbesartan) or control was evaluated on Inhibition of U46619- or endothelin-1-induced contractions. Telmisartan inhibited vasoconstriction in mouse resistance arteries through a PPARγ-dependent increase in eNOS expression and activity, independent of AT1R blockade.
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