Population
Vascular smooth muscle cells derived from the thoracic aorta of Wistar-Kyoto rat
Comparison
Telmisartan vs Other AT1R antagonists (candesartan or olmesartan)
Design
Preclinical
Authors
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Should not change ARB selection in patients; hypothesis-generating for PPARγ-mediated effects in vascular models.
Telmisartan uniquely downregulates AT1R gene expression through PPARgamma activation in vascular smooth muscle cells, providing dual inhibition of angiotensin II function.
Imayama et al. (2006) studied this question.
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