Why the study?
Does losartan improve recovery of cardiac function and metabolism after ischemia-reperfusion in isolated rat hearts?
Population
Isolated perfused rat hearts subjected to 15 minutes of global ischemia and 30 minutes of postischemic…
Comparison
Losartan or quinaprilat administered pre- and… vs Untreated control hearts
Design
Preclinical
Follow-up
30 minutes of postischemic reperfusion
Authors
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Indicates bradykinin-dependent protection by losartan in rat hearts; leaves open clinical translation and human mechanism confirmation.
Does losartan improve recovery of cardiac function and metabolism after ischemia-reperfusion in isolated rat hearts?
Losartan protects the heart against acute ischemia-reperfusion injury through an unexpectedly bradykinin-dependent mechanism.
Zhu et al. (1999) studied this question.
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