Why the study?
Does intermittent losartan or irbesartan administration trigger cardiac post-conditioning in isolated rat hearts?
Population
Isolated rat hearts subjected to 30 min ischemia and 120 min reperfusion
Comparison
Intermittent or continuous losartan or… vs Hearts subjected to ischemia/reperfusion alone
Design
Preclinical
Follow-up
120 min reperfusion
Authors
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Should not yet alter clinical ARB use; leaves open whether intermittent losartan confers post-ischemic protection in humans.
Does intermittent losartan or irbesartan administration trigger cardiac post-conditioning in isolated rat hearts?
Intermittent losartan, but not irbesartan, mediates post-conditioning cardioprotection in isolated rat hearts, likely through modulation of BK2 receptors rather than AT1 receptor blockade.
Sgarra et al. (2014) studied this question.
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