Why the study?
Does adiponectin improve left ventricular systolic dysfunction in mice with LPS-induced acute cardiac injury?
Population
Wild-type and adiponectin-knockout mice subjected to a single intraperitoneal dose of lipopolysaccharide
Comparison
Systemic delivery of an adenoviral vector… vs Wild-type mice or untreated APN-KO mice
Design
Preclinical
Authors
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Hypothesis-generating for adiponectin in sepsis cardiomyopathy; human studies required before any clinical consideration.
Does adiponectin improve left ventricular systolic dysfunction in mice with LPS-induced acute cardiac injury?
Adiponectin protects against endotoxin-induced acute cardiac injury by suppressing inflammatory responses, highlighting a potential therapeutic target for sepsis-associated myocardial dysfunction.
Watanabe et al. (2014) studied this question.
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