Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury
Key result
Adiponectin protects against inflammation and injury in murine autoimmune myocarditis by diminishing TLR4 signalling, thereby attenuating inflammatory activation of cardiac and immune cells.
Population
Murine experimental autoimmune myocarditis model, APN-knockout mice, and in vitro cardiac and immune cells
Comparison
Adiponectin overexpression and APN administration vs Control mice/cells (implied)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in murine myocarditis; extends TLR4 mechanisms but leaves open human translation.
Structured PICO
P
Population
Murine experimental autoimmune myocarditis (EAM) model, APN-knockout (APN-KO) mice, and in vitro cardiac and immune cells
I
Intervention
Adiponectin (APN) overexpression (in vivo) and APN administration (in vitro)
C
Comparator
Control mice/cells (implied)
O
Outcome
Cardiac inflammation and injury (TLR4 expression, downstream inflammatory targets, immune cell infiltration, and myocardial apoptosis)surrogate
Adiponectin protects against inflammation and injury in autoimmune myocarditis by inhibiting TLR4 signaling through COX-2, PKA, and MEK1 pathways.
Cite This Study
Jenke et al. (2013) studied Autoimmune myocarditis. Adiponectin (APN) vs. APN-knockout or control was evaluated on Inflammation and injury in autoimmune myocarditis. Adiponectin protects against inflammation and injury in murine autoimmune myocarditis by diminishing TLR4 signalling, thereby attenuating inflammatory activation of cardiac and immune cells.