Why the study?
Does angiotensin II stimulate TLR4 transcription in specific renal cells?
Population
Cultured murine proximal tubular cells, murine mesangial cells, and murine podocytes
Comparison
Angiotensin II (ANG II) treatment vs Untreated cells and comparison across different…
Design
Preclinical
Authors
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May inform mechanisms of ANG II-mediated renal inflammation in mesangial cells and podocytes; leaves open translation to human disease or therapy.
Does angiotensin II stimulate TLR4 transcription in specific renal cells?
Angiotensin II upregulates TLR4 transcription in mesangial cells and podocytes via AP1 and PU.1 sites, suggesting a mechanism for ANG II-mediated renal inflammation.
Bondeva et al. (2007) studied this question.
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