What question did this study set out to answer?

To evaluate whether ginsenosides Rb3 and Rd act as prebiotics to restore gut microbial balance, improve intestinal barrier integrity, and prevent polyp formation in an ApcMin/+ mouse model.

September 26, 2017Scientific ReportsOpen Access

Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice

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Authors

GHGuoxin HuangNankai University IKImran KhanMacau University of Science and Technology XLXiaoang LiMacau University of Science and Technology

Discussion

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Implication

Preclinical study reveals ginsenosides Rb3 and Rd suppress intestinal polyps and reverse gut dysbiosis in mice, highlighting prebiotic potential against colorectal cancer.

Key Points

To evaluate whether ginsenosides Rb3 and Rd act as prebiotics to restore gut microbial balance, improve intestinal barrier integrity, and prevent polyp formation in an ApcMin/+ mouse model.
Treated ApcMin/+ mice with non-toxic prebiotic doses of ginsenoside-Rb3 and ginsenoside-Rd.
Evaluated polyp size, polyp number, epithelial architecture (goblet and Paneth cell counts; E-cadherin and N-cadherin levels), and oncogenic signaling (iNOS, STAT3/pSTAT3, Src/pSrc).
Characterized changes in mucosal inflammatory cytokine expression and gut microbiota composition.
Both Rb3 and Rd significantly reduced polyp number and size while downregulating oncogenic signaling proteins (iNOS, pSTAT3, and pSrc).
Treatment restored mucosal barrier structure by increasing goblet and Paneth cells, re-establishing cadherin expression, and shifting cytokine balance toward an anti-inflammatory profile.
Ginsenosides enriched beneficial bacteria (Bifidobacterium spp., Lactobacillus spp., and Bacteroides species) while reducing cancer cachexia-associated taxa such as Dysgonomonas spp. and Helicobacter spp.

Cite This Study

Huang et al. (2017) studied this question.

synapsesocial.com/papers/6a8904daab71709247a2ac3f https://doi.org/10.1038/s41598-017-12644-5

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Implication

Preclinical study reveals ginsenosides Rb3 and Rd suppress intestinal polyps and reverse gut dysbiosis in mice, highlighting prebiotic potential against colorectal cancer.

Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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