What does this research mean for the field?

20(S/R)-ginsenoside Rh1 suppresses colorectal cancer progression by modulating gut microbiota, regulating tryptophan metabolism to activate AhR/PXR pathways, and inhibiting IDO1-mediated immune suppression. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study investigates how 20(S/R)-ginsenoside Rh1 impacts colorectal cancer via gut microbiota and tryptophan metabolism modulation.

June 19, 2026International Journal of Molecular SciencesOpen Access

20(S/R)-Ginsenoside Rh1 Alleviates AOM/DSS-Induced Colorectal Cancer: Gut-Microbiota Modulation and Tryptophan-Metabolism-Mediated AhR/PXR Activation and IDO1

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Authors

LLLinqian LuJilin Academy of Agricultural Sciences JMJinyu MinChangchun University of Chinese Medicine YGYu GaoQiqihar University

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Implication

Randomized trial shows Ginsenoside Rh1 reduces colorectal cancer progression in mice, suggesting therapeutic potential.

Key Points

This study investigates how 20(S/R)-ginsenoside Rh1 impacts colorectal cancer via gut microbiota and tryptophan metabolism modulation.
AOM/DSS-induced colorectal cancer mouse model was utilized.
Mice were treated with 100 mg·kg−1·day−1 of 20(S/R)-ginsenoside Rh1 for 6 weeks.
Assessment included monitoring disease activity index, colon length, and tumor count.
Ginsenoside Rh1 significantly decreased the disease activity index and tumor count.
Increased gut microbial diversity and beneficial bacteria like Lactobacillus were observed.
Activated pathways related to intestinal barrier function and reduced inflammatory cytokines while enhancing IL-10 levels.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a34dfa365a5b0777af2ebcc https://doi.org/10.3390/ijms27125477

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20(S/R)-Ginsenoside Rh1 Alleviates AOM/DSS-Induced Colorectal Cancer: Gut-Microbiota Modulation and Tryptophan-Metabolism-Mediated AhR/PXR Activation and IDO1

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Key Points

Cite This Study

20(S/R)-Ginsenoside Rh1 Alleviates AOM/DSS-Induced Colorectal Cancer: Gut-Microbiota Modulation and Tryptophan-Metabolism-Mediated AhR/PXR Activation and IDO1

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