What question did this study set out to answer?

To evaluate experimental and clinical evidence regarding the regulatory roles of prolactin and growth hormone in immune system function.

October 1, 1991Experimental Biology and Medicine

Prolactin and Growth Hormone in the Regulation of the Immune System

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Authors

RGRichard R. GalaBoston University

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Implication

Narrative review demonstrates that prolactin and growth hormone restore immune responses across animal models, highlighting their direct role in regulating cell-mediated and humoral immunity.

Key Points

To evaluate experimental and clinical evidence regarding the regulatory roles of prolactin and growth hormone in immune system function.
Synthesized findings from hypophysectomized, bromocriptine-treated, and genetically dwarf animal models assessing humoral and cell-mediated immunity.
Reviewed in vitro studies examining immune cell proliferation, receptor expression, endogenous hormone synthesis, and thymic hormone secretion.
Deficiencies in cell-mediated and humoral immune functions induced by hypophysectomy, bromocriptine, or genetic dwarfism are reversed by either prolactin or growth hormone administration.
Both prolactin and growth hormone stimulate thymic function and elevate thymulin secretion across species, with growth hormone-induced cell proliferation mediated by insulin-like growth factor I.
Immune cells express high-affinity prolactin and growth hormone receptors, and prolactin-specific antisera block key immune reactions in vitro.

Cite This Study

Richard R. Gala (1991) studied this question.

synapsesocial.com/papers/6a8905fa3fe85f489c1ff0b7 https://doi.org/10.3181/00379727-198-43286b

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Implication

Narrative review demonstrates that prolactin and growth hormone restore immune responses across animal models, highlighting their direct role in regulating cell-mediated and humoral immunity.

Prolactin and Growth Hormone in the Regulation of the Immune System

Discussion

Member takes

Implication

Key Points

Cite This Study

Prolactin and Growth Hormone in the Regulation of the Immune System

Discussion

Member takes

Implication

Key Points

Cite This Study

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