Population
Horse and dog thyroid soluble fraction, and dog thyroid slices
Comparison
Various biochemical modulators including EGTA… vs Control conditions without specific modulators
Design
Preclinical
Authors
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Supports cGMP-PDE mediation of cholinergic thyroid cAMP effects; hypothesis-generating, should not change practice.
The study suggests that cholinergic inhibitory effects on cyclic AMP accumulation in the thyroid are mediated by cyclic GMP through direct activation of phosphodiesterase activity.
Erneux et al. (1977) studied this question.
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