January 1, 1983Folia Endocrinologica JaponicaOpen Access

The Effect of Several Hormones on the Cyclic 3′, 5′-Nucleoncle Phosphodiesterase in Rat Kidney

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Population

Rat kidney (cortex and medulla) from Oxford Hooded male rats

Design

Preclinical

Authors

KIKatsumi IwaseAsahi Kasei (Germany)

Discussion

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Implication

Animal findings on hormone-PDE interactions leave open any human renal effects; in vivo studies needed before clinical consideration.

Structured PICO

Population

Rat kidney (cortex and medulla) from Oxford Hooded male rats

Intervention

In vitro application of 1 alpha, 25(OH)2 Vit D3, parathyroid hormone (PTH), antidiuretic hormone (ADH), calcitonin (CT), angiotensin II, and trichlormethiazide

Outcome

Cyclic AMP- and cyclic GMP-phosphodiesterase (cAMP-PDE and cGMP-PDE) activitiessurrogate

Certain hormones (1a,25(OH)2 Vit D3, CT, ADH) regulate kidney function by affecting cAMP-PDE and/or cGMP-PDE activities in vitro, suggesting a role in cyclic nucleotide metabolism.

Cite This Study

Katsumi Iwase (1983) studied this question.

synapsesocial.com/papers/6a94d0a22ea3449151e60e0e https://doi.org/10.1507/endocrine1927.59.10_1678

View Full Paper

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The Effect of Several Hormones on the Cyclic 3′, 5′-Nucleoncle Phosphodiesterase in Rat Kidney

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Effect of Several Hormones on the Cyclic 3′, 5′-Nucleoncle Phosphodiesterase in Rat Kidney

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider