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In real-world aCL testing, higher initial ELISA values are associated with a greater likelihood of persistent positivity at 12 weeks.
We conducted a prospective study of anticardiolipin antibody (aCL) testing, performed in our university hospital. Among 6321 consecutive patients tested for both IgG and IgM aCL, 91 patients with medium or high positivity (>99th percentile) had a subsequent confirmatory test. Among them, 53 had a persistent positivity at 12 weeks. In this real world setting, patients with transient positivity had lower values than patients with persistent positivity.
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Wahl et al. (2012) studied this question.
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