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March 4, 2007Microcirculation

Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Remodeling in Interval Sprint Trained Skeletal Muscle

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Why the study?

Does high-intensity interval sprint training improve flow capacity and microvascular hemodynamics in rat skeletal muscle?

Population

Rats (white/mixed-fiber portion of gastrocnemius muscles)

Comparison

High-intensity interval sprint training vs Sedentary (SED) control rats

Design

Preclinical

Follow-up

10 weeks

Authors

KBKyle BinderForest InstituteWMWalter L. MurfeeUniversity of FloridaJSJi SongUniversity of Virginia

Discussion

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Implication

May enhance rat muscle perfusion via arteriolar remodeling; hypothesis-generating for human microvascular responses to sprint training.

Structured PICO

Does high-intensity interval sprint training improve flow capacity and microvascular hemodynamics in rat skeletal muscle?

P
Population
Rats (white/mixed-fiber portion of gastrocnemius muscles)
I
Intervention
High-intensity interval sprint training (IST) (6 bouts of running/day; 2.5 min/bout; 60 m/min speed; 15% grade; 4.5 min rest between bouts; 5 training days/wk; 10 wks total)
C
Comparator
Sedentary (SED) control rats
O
Outcome
Arteriolar adaptation, flow capacity, and local microvascular hemodynamicssurrogate

Interval sprint training doubles flow capacity in skeletal muscle by increasing arterioles in the 3A through 6A generations, allowing deeper penetration of high pressure into the network.

Cite This Study

Binder et al. (2007) studied this question.

synapsesocial.com/papers/6a890e24eb3171c94f1ff46bhttps://doi.org/10.1080/10739680601139237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise Training Produces Nonuniform Increases in Arteriolar Density of Rat Soleus and Gastrocnemius Muscle2006 · 41 citations
  2. 2Interval sprint training enhances endothelial function and eNOS content in some arteries that perfuse white gastrocnemius muscle2004 · 85 citations
  3. 3Influence of endurance exercise training on distribution of vascular adaptations in rat skeletal muscle1994 · 49 citations
  4. 4Vascular remodeling enhances high-flow muscle oxygen delivery following aerobic exercise training2026 · 1 citations
  5. 5Flow‐mediated dilation and exercise‐induced hyperaemia in highly trained athletes: comparison of the upper and lower limb vasculature2008 · 81 citations