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January 1, 2004Journal of Applied Physiology

Interval sprint training for 10 weeks enhanced acetylcholine-induced dilation and eNOS content nonuniformly among arteries and arterioles that perfuse the white gastrocnemius muscle in rats.

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Why the study?

Does interval sprint training improve endothelium-dependent dilation and eNOS content in arteries perfusing white gastrocnemius muscle in rats?

Population

Male Sprague-Dawley rats (n=125)

Comparison

Interval sprint training for 10 weeks vs Sedentary (Sed) control

Design

Preclinical

Follow-up

10 weeks

Key result

Interval sprint training for 10 weeks enhanced acetylcholine-induced dilation and eNOS content nonuniformly among arteries and arterioles that perfuse the white gastrocnemius muscle in rats.

Authors

MLM. H. LaughlinCWChristopher R. WoodmanWSWilliam G. Schrage

Discussion

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Overview

Should not change human exercise prescriptions; leaves open translation of nonuniform rat vascular adaptations.

Structured PICO

Does interval sprint training improve endothelium-dependent dilation and eNOS content in arteries perfusing white gastrocnemius muscle in rats?

P
Population
125 male Sprague-Dawley rats subjected to 10 weeks of interval sprint training or sedentary conditions.
I
Intervention
Interval sprint training (IST) for 10 weeks (six 2.5-min exercise bouts, with 4.5 min of rest between bouts at 60 m/min, 15% incline, 5 days/wk)
C
Comparator
Sedentary (Sed) control
O
Outcome
Endothelium-dependent dilation (EDD) and endothelial nitric oxide synthase (eNOS) protein content in arteries and arterioles perfusing the white portion of rat gastrocnemius musclesurrogate

Interval sprint training induces non-uniform vascular adaptations, enhancing endothelium-dependent dilation and eNOS content in specific arteries perfusing the white gastrocnemius muscle.

Cite This Study

Laughlin et al. (2004) studied this question. Interval sprint training (IST) vs. Sedentary was evaluated on Endothelium-dependent dilation (EDD) and eNOS content in arteries/arterioles perfusing white gastrocnemius muscle. Interval sprint training for 10 weeks enhanced acetylcholine-induced dilation and eNOS content nonuniformly among arteries and arterioles that perfuse the white gastrocnemius muscle in rats.

synapsesocial.com/papers/6a26c6e3b722b3620db3422bhttps://doi.org/10.1152/japplphysiol.00105.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise Training Produces Nonuniform Increases in Arteriolar Density of Rat Soleus and Gastrocnemius Muscle2006 · 40 citations
  2. 2Nonuniform effects of endurance exercise training on vasodilation in rat skeletal muscle2004 · 77 citations
  3. 3Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats1994 · 173 citations
  4. 4Functional adaptations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat2012 · 31 citations
  5. 5Time course of enhanced endothelium-mediated dilation in aorta of trained rats1997 · 165 citations