What question did this study set out to answer?

This study aims to determine the time course of exercise-induced adaptations in aortic endothelial function in rats.

Time course of enhanced endothelium-mediated dilation in aorta of trained rats

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Caution against extrapolating rat aortic data to patients; leaves open translation of exercise-induced endothelial adaptations to humans.

This study aims to determine the time course of exercise-induced adaptations in aortic endothelial function in rats.
Male rats were divided into sedentary and exercise groups with varying durations of training (1 WK to 10 WK).
Exercise consisted of treadmill running at 30 m.min-1 for 1 hour, five days a week for specified durations.
Maximal vasodilator responses to acetylcholine were measured in abdominal aortic rings.
ACh-induced dilation was greater in the 4 WK (72 +/- 2%) and 10 WK (79 +/- 1%) groups compared to sedentary (61 +/- 2%).
Citrate synthase activity was significantly higher in 2 WK (31 +/- 1), 4 WK (34 +/- 2), and 10 WK (36 +/- 1) rats than in sedentary (27 +/- 1).
ACh-mediated relaxation was preserved with cyclooxygenase inhibition but abolished with nitric oxide synthase inhibition.

Delp et al. (1997) studied this question.

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