Key result
Six weeks of regular exercise increased sensitivity to acetylcholine twofold compared to a single bout of exercise, with improvements lasting up to 192 hours.
Why the study?
Does 6 weeks of regular exercise improve and prolong endothelium-dependent vasorelaxation compared to a single bout of exercise in female Sprague-Dawley rats?
Population
Female Sprague-Dawley rats
Comparison
6 weeks of regular exercise vs A single bout of exercise
Design
Preclinical, Rats were randomized
Follow-up
Up to 192 hours post-exercise
Authors
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Hypothesis-generating for sustained endothelial benefits of training in rats; should not yet alter clinical exercise prescriptions.
RCT
randomized
Does 6 weeks of regular exercise improve and prolong endothelium-dependent vasorelaxation compared to a single bout of exercise in female Sprague-Dawley rats?
Regular exercise induces a larger and longer-lasting improvement in endothelium-dependent vasorelaxation compared to a single bout of exercise in a rat model.
Haram et al. (2006) reported an RCT. 6 weeks of regular exercise vs. Single bout of exercise was evaluated on Endothelium-dependent dilation (vascular responsiveness to acetylcholine). Six weeks of regular exercise increased sensitivity to acetylcholine twofold compared to a single bout of exercise, with improvements lasting up to 192 hours.
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