Population
Rats (spinotrapezius muscle microvessels)
Comparison
High-salt diet (7% NaCl) for 4-5 weeks vs Normal diet (0.45% NaCl) for 4-5 weeks
Design
Preclinical
Follow-up
4-5 weeks
Authors
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Alternate ROS sources likely mediate high-salt endothelial impairment in rats; hypothesis-generating and should not yet inform clinical practice.
A high-salt diet increases basal microvascular oxidant enzyme activity in rats, but an alternate source of reactive oxygen species appears responsible for the impaired endothelium-dependent dilation to acetylcholine.
Lenda et al. (2002) studied this question.
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