Why the study?
Does chloride channel blockade with IAA-94 attenuate renal arteriolar contractile responses to angiotensin II in enalaprilat-treated rats?
Population
Enalaprilat-treated rats (in vitro blood-perfused juxtamedullary nephron technique)
Comparison
Chloride channel blocker 30 mumol/L vs Control conditions (without IAA-94)
Design
Preclinical
Authors
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Supports selective afferent arteriolar AngII modulation via chloride channels in rats; leaves open any human therapeutic relevance.
Does chloride channel blockade with IAA-94 attenuate renal arteriolar contractile responses to angiotensin II in enalaprilat-treated rats?
Chloride channels are required for the full expression of AngII-induced afferent, but not efferent, arteriolar vasoconstriction in rats.
Pamela K. Carmines (1995) studied this question.
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