Population
Cultured vascular smooth muscle cells (VSMC) and isolated perfused hydronephrotic kidneys (IPHK)
Comparison
Indanyloxyacetic acid (IAA-94) 30 microM vs Control (endothelin alone)
Design
Preclinical
Authors
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Does not support clinical use of IAA-94; leaves open chloride channel targeting in endothelin-mediated renal vasoconstriction.
The chloride channel inhibitor IAA-94 attenuates endothelin-induced vasoconstriction, suggesting that chloride channel opening and subsequent membrane depolarization contribute to endothelin's vasoconstrictor mechanisms.
Takenaka et al. (1992) studied this question.
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