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This is a In Vitro Study study.

October 18, 2025Hypertension

Abstract TAC156: Inhibition Of Macrophage Activation By Indole-3-acetic acid, a Metabolite Produced By The Gut Microbiota

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IAA reduced IL-6, IL-17, and TNF-α production by 190%, 130%, and 200%, respectively, indicating its anti-inflammatory potential.
The leukocyte adhesion assay showed a 110% reduction in macrophage attachment to endothelial cells when pretreated with 100 nM IAA.
In vivo implications include IAA's potential to mitigate kidney dysfunction in hypertensive models, highlighting its significance in vascular health.
Inhibition of ETAR and ETBR by IAA suggests a dual-action mechanism, targeting pathways involved in hypertension and inflammation.

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Inhibition of ET receptors by indole-3-acetic acid reduces macrophage activation, suggesting potential in treating kidney dysfunction.

Menon et al. (2025) studied this question.

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