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March 4, 2022Journal of the American Heart AssociationOpen Access

Practice Patterns and Outcomes of Transcatheter Aortic Valve Replacement in the United States and Japan: A Report From Joint Data Harmonization Initiative of STS/ACC TVT and J‐TVT

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Why the study?

Practice patterns and outcomes of medical devices postapproval may differ by country, motivating a direct comparison of national TAVR registry data between the United States and Japan.

Do patient characteristics and periprocedural outcomes of transcatheter aortic valve replacement differ between the United States and Japan?

Population

244 722 TAVRs from 646 US institutions and 26 673 TAVRs from 171 Japanese institutions

Comparison

TAVR in Japan vs TAVR in the United States

Design

Binational harmonized registry study

Follow-up

30-day

Discussion

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Member takes

Overview

TAVR outcomes favor Japan despite higher risk; hypothesis-generating for practice differences and requires prospective validation.

Structured PICO

Do patient characteristics and periprocedural outcomes of transcatheter aortic valve replacement differ between the United States and Japan?

P
Population
271,395 patients undergoing transcatheter aortic valve replacement (TAVR) between 2013 and 2019, including 244,722 from 646 institutions in the United States and 26,673 from 171 institutions in Japan.
I
Intervention
Transcatheter aortic valve replacement (TAVR) in Japan
C
Comparator
Transcatheter aortic valve replacement (TAVR) in the United States
O
Outcome
30-day mortality and composite outcomes of death, stroke, and bleedingcomposite

Despite being older and having a higher predicted risk of mortality, TAVR patients in Japan had lower 30-day mortality and major morbidity compared to those in the United States, highlighting international practice differences.

Cite This Study

A 2022 study studied this question.

synapsesocial.com/papers/6a89123f30fc94fc4b130f02https://doi.org/10.1161/jaha.121.023848

Topics

Transcatheter aortic valve replacementTAVR in low-risk patients
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery2010 · 7,245 citations
  2. 2Annual Outcomes With Transcatheter Valve Therapy2015 · 264 citations
  3. 3The German Aortic Valve Registry (GARY): in-hospital outcome2013 · 337 citations
  4. 4Comparative Trends in Percutaneous Coronary Intervention in Japan and the United States, 2013 to 20172020 · 153 citations
  5. 5Ten-year experience with transcatheter and surgical aortic valve replacement in Finland2019 · 22 citations