Local paclitaxel delivery via stents, balloons, or catheters aims to optimize therapeutic efficacy and minimize systemic side effects in the treatment of peripheral arterial disease.
L ocal drug delivery is the process by which therapeutic agents are administered to targeted segments of the circulatory system to treat vascular disease. The aims are to optimize therapeutic efficacy by direct drug administration and to minimize untoward effects associated with systemic delivery. This is accomplished in humans with drug-eluting stents (DES), drug-coated balloons (DCB), and direct catheter delivery.
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Hawkins et al. (2011) studied this question.
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