Local drug delivery: Impact of pressure, substance characteristics, and stenting on drug transfer into the arterial wall
Population
Freshly explanted porcine hearts (left anterior descending artery)
Comparison
Local drug delivery of tritiated reviparin or… vs Comparison between reviparin and paclitaxel…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Preclinical data favor lipophilic agents for local delivery; leaves open translation to human efficacy and safety.
Structured PICO
P
Population
Freshly explanted porcine hearts (left anterior descending artery)
I
Intervention
Local drug delivery of tritiated reviparin (hydrophilic) or paclitaxel (lipophilic) via Infusasleeve II catheter system at various infusion pressures (40, 60, 80, 100 psi) and with/without stenting
C
Comparator
Comparison between reviparin and paclitaxel, different infusion pressures, and presence vs absence of stenting
O
Outcome
Percentage of totally delivered activity found in the vessel wallsurrogate
Lipophilic drugs like paclitaxel achieve significantly higher arterial wall concentrations during local catheter-based delivery compared to hydrophilic drugs like reviparin, independent of injection pressure or stenting.
Cite This Study
Baumbach et al. (1999) studied this question.