February 18, 2004Investigative Radiology
Inhibition of Restenosis in Stented Porcine Coronary Arteries
Why the study?
Does intracoronary injection of paclitaxel-containing contrast medium result in adequate local tissue concentrations in stented porcine coronary arteries?
Structured PICO
Does intracoronary injection of paclitaxel-containing contrast medium result in adequate local tissue concentrations in stented porcine coronary arteries?
P
Population
15 pigs receiving 2 stents each in the left coronary artery (porcine coronary overstretch model)
I
Intervention
Intracoronary injection of paclitaxel-containing contrast medium (CM) or diluted paclitaxel (Taxol) during and/or after stenting
C
Comparator
Comparison between different paclitaxel doses and preparations (paclitaxel in CM vs. diluted Taxol)
O
Outcome
Early local tissue concentrations of paclitaxel in the arterial wall and myocardium measured by high-performance liquid chromatography 15 minutes after the last intracoronary injectionsurrogate
Paclitaxel admixed to contrast medium achieves dose-proportional, selective local tissue concentrations in stented porcine coronary arteries, supporting its potential for inhibiting restenosis.
Authors
Discussion
No takes yet. Share an insight, caveat, or question.
Implication
Hypothesis-generating for contrast-mediated local paclitaxel delivery in stented arteries; human trials needed before any clinical consideration.
Cite This Study
Speck et al. (2004) studied this question.