Key result
Iopromide-protaxel injection reduces neointimal area ~34% after coronary stenting in a porcine model.
Why the study?
Lipophilic taxanes can be dissolved in contrast media at higher concentrations than saline, suggesting contrast media may serve as a matrix for local antiproliferative drug delivery to prevent restenosis after coronary stenting.
Does a taxane-contrast agent formulation reduce in-stent restenosis in a porcine coronary stent model?
Does a taxane-contrast agent formulation reduce in-stent restenosis in a porcine coronary stent model?
Effect estimate: 34% reduction
Using a contrast agent as a solvent for a taxane provides a novel local drug delivery mechanism that successfully inhibits in-stent restenosis in a porcine model.
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Novel taxane-contrast formulation feasible for local delivery; leaves open whether it reduces restenosis after stenting.
Bruno Scheller (2003) studied in-stent restenosis (n=8). iopromide-protaxel formulation vs. iopromide 370 alone was evaluated on neointimal area (34% reduction). Injection of an iopromide-protaxel formulation during coronary stenting in a porcine model reduced the neointimal area by 34% at 28 days compared to iopromide alone.
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