Key result
Local delivery of paclitaxel with a double-balloon perfusion catheter prior to stenting did not reduce neointimal thickness (1.0 vs 0.7 mm) compared to stenting alone in pig coronary arteries.
Why the study?
Does local delivery of paclitaxel using a double-balloon perfusion catheter before stenting reduce neointima formation in porcine coronary arteries?
Population
27 domestic pigs undergoing stent implantation of the left anterior descending artery
Comparison
Paclitaxel delivered locally using a… vs Stent implantation only
Design
Preclinical
Follow-up
4 weeks
Authors
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Negative porcine result; leaves open whether refined local paclitaxel delivery could limit neointimal hyperplasia in humans.
Does local delivery of paclitaxel using a double-balloon perfusion catheter before stenting reduce neointima formation in porcine coronary arteries?
Absolute Event Rate: 1% vs 0.7%
Local delivery of paclitaxel via a double-balloon perfusion catheter prior to stenting does not reduce neointima formation in a porcine coronary model.
Oberhoff et al. (2001) studied Coronary stent implantation (n=27). Paclitaxel local delivery using double-balloon perfusion catheter vs. Stent implantation only was evaluated on Neointimal thickness (mm). Local delivery of paclitaxel with a double-balloon perfusion catheter prior to stenting did not reduce neointimal thickness (1.0 vs 0.7 mm) compared to stenting alone in pig coronary arteries.
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