Population
Post-natal mice and in vitro models
Comparison
Engineered zinc finger DdCBEs delivered via a single AAV9
Design
Preclinical in vitro and in vivo study
Authors
Loading...
ZF-DdCBEs extend base editing beyond TALE arrays; leaves open therapeutic translation pending in vivo validation.
The development of compact zinc finger base editors enables precise editing of organelle or nuclear DNA without double-strand breaks in vivo, providing a new research tool despite current off-target limitations.
Willis et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: