The transition state of the dienone-phenol rearrangement of 1 to 2 is mimicked by hapten 3. An immune response to 3 yielded an antibody (62C7) which was found to catalyze the rearrangement efficiently. It was shown that 62C7 does not act as a simple acid catalyst, but rather selectively stabilizes the charge distribution in the transition state.
No takes yet. Share an insight, caveat, or question.
Chen et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: