What question did this study set out to answer?

To assess the hemodynamic effects of multiple doses of furosemide on horses before, during, and after high-speed treadmill exercise.

May 1, 1992American Journal of Veterinary Research

Influence of furosemide on hemodynamic responses during exercise in horses

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Authors

SOSteven C. OlsenAgricultural Research Service CCC.P. CoyneMississippi State University BLB. LoweAuckland City Hospital

Discussion

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Implication

Experimental trial demonstrates dose-dependent reduction of pulmonary and right atrial pressures by furosemide in exercising horses, indicating vasodilatory effects beyond diuresis.

Key Points

To assess the hemodynamic effects of multiple doses of furosemide on horses before, during, and after high-speed treadmill exercise.
Six horses received four intravenous doses of furosemide (0.25, 0.50, 1.0, and 2.0 mg/kg) or a saline control (10 ml 0.9% NaCl) four hours prior to treadmill exercise.
Cardiovascular variables—including carotid arterial pressure, pulmonary arterial pressure, right atrial pressure, and heart rate—as well as hematologic indices were measured at rest, during graded exercise, and during recovery.
Furosemide at 0.25 to 2.0 mg/kg produced dose-dependent reductions in right atrial pressure and pulmonary arterial pressure during exercise without altering heart rate or plasma lactate concentration.
Mean carotid arterial pressure decreased with 2.0 mg/kg furosemide during exercise at 9 and 11 m/s, but not at 13 m/s, while resting right atrial pressure was reduced four hours post-injection.
Exercise and recovery packed cell volume and hemoglobin concentrations increased in a dose-dependent manner, though changes were small relative to the marked pressure decreases.

Cite This Study

Olsen et al. (1992) studied this question.

synapsesocial.com/papers/6a891581d5f4e697bb1320c7 https://doi.org/10.2460/ajvr.1992.53.05.742

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May 1, 1992American Journal of Veterinary Research

Influence of furosemide on hemodynamic responses during exercise in horses

View Full Paper

Ask AI

Bookmark

Authors

SOSteven C. OlsenAgricultural Research Service CCC.P. CoyneMississippi State University BLB. LoweAuckland City Hospital

Discussion

Member takes

Implication

Experimental trial demonstrates dose-dependent reduction of pulmonary and right atrial pressures by furosemide in exercising horses, indicating vasodilatory effects beyond diuresis.

Key Points

To assess the hemodynamic effects of multiple doses of furosemide on horses before, during, and after high-speed treadmill exercise.
Six horses received four intravenous doses of furosemide (0.25, 0.50, 1.0, and 2.0 mg/kg) or a saline control (10 ml 0.9% NaCl) four hours prior to treadmill exercise.
Cardiovascular variables—including carotid arterial pressure, pulmonary arterial pressure, right atrial pressure, and heart rate—as well as hematologic indices were measured at rest, during graded exercise, and during recovery.
Furosemide at 0.25 to 2.0 mg/kg produced dose-dependent reductions in right atrial pressure and pulmonary arterial pressure during exercise without altering heart rate or plasma lactate concentration.
Mean carotid arterial pressure decreased with 2.0 mg/kg furosemide during exercise at 9 and 11 m/s, but not at 13 m/s, while resting right atrial pressure was reduced four hours post-injection.
Exercise and recovery packed cell volume and hemoglobin concentrations increased in a dose-dependent manner, though changes were small relative to the marked pressure decreases.

Cite This Study

Olsen et al. (1992) studied this question.

synapsesocial.com/papers/6a891581d5f4e697bb1320c7 https://doi.org/10.2460/ajvr.1992.53.05.742

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