Key result
Furosemide lowers warm-up pulmonary trunk pressure vs. saline without altering race times in horses.
Why the study?
The effects of furosemide on cardiovascular function and performance under simulated racing conditions were not well characterized.
Does furosemide improve cardiovascular function and performance in Standardbred horses prior to simulated races?
Comparison
Furosemide 1 mg/kg IV vs saline solution IV before warm-up workouts
Design
Double-blind study
Follow-up
135 minutes after injection
Authors
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Reduces pulmonary pressure in equine warm-up without performance gains; hypothesis-generating for veterinary exercise physiology.
RCT (n=6)
Double-blind
Does furosemide improve cardiovascular function and performance in Standardbred horses prior to simulated races?
p-value: p=< 0.05
Furosemide lowers pulmonary trunk pressure during warm-up in horses but does not improve simulated race performance.
Milne et al. (1980) conducted an RCT in Simulated racing (n=6). Furosemide vs. Saline solution IV was evaluated on Pulmonary trunk pressure during the first warm-up workout (p=< 0.05). Furosemide significantly lowered pulmonary trunk pressure during a warm-up workout (P<0.05) but did not significantly change average simulated race times compared with saline in horses.
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