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January 18, 2018BMC Veterinary ResearchOpen Access

Prospective pre- and post-race evaluation of biochemical, electrophysiologic, and echocardiographic indices in 30 racing thoroughbred horses that received furosemide

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Why the study?

Does high level racing alter cardiac function, electrophysiologic parameters, and biochemical markers in Thoroughbred horses receiving furosemide?

Population

30 Thoroughbred horses, age 3-6 years, receiving furosemide prior to racing

Comparison

High level racing vs Pre-race baseline

Design

Preclinical

Follow-up

24 hours post-race

Authors

CGCatherine T. Gunther‐HarringtonUniversity of California, DavisRARick M. ArthurUniversity of California, DavisKEKrista EstellMarion duPont Scott Equine Medical Center

Discussion

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Implication

Transient post-race cardiac changes in furosemide-treated Thoroughbreds appear reversible by 24 hours; leaves open longitudinal effects on equine athletes.

Structured PICO

Does high level racing alter cardiac function, electrophysiologic parameters, and biochemical markers in Thoroughbred horses receiving furosemide?

P
Population
30 Thoroughbred horses, age 3-6 years, receiving furosemide prior to racing
I
Intervention
High level racing
C
Comparator
Pre-race baseline (each horse served as its own control)
O
Outcome
Indices of cardiac function, electrophysiologic parameters, and biochemical markers of heart dysfunction (including heart rate, ECG, echocardiogram, electrolytes, hematocrit, cardiac troponin I, and partial pressure CO2)surrogate

High level racing in Thoroughbred horses receiving furosemide induces transient increases in heart rate, systolic function, and cardiac troponin I, which return to baseline within 24 hours.

Limitations

  • Before and after study design where each horse served as its own control
  • Possible effect of regression to the mean cannot be ruled out

Cite This Study

Gunther‐Harrington et al. (2018) studied this question.

synapsesocial.com/papers/6a09930616dfdfe7ed343307https://doi.org/10.1186/s12917-018-1336-0

Topics

EchocardiographyValvular heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular Arrhythmias during Race Recovery in Standardbred Racehorses and Associations with Autonomic Activity2010 · 96 citations
  2. 2Cardiac Troponin I in Racing Standardbreds2012 · 37 citations
  3. 3Cardiac Troponin I in Pastured and Race-Training Thoroughbred Horses2003 · 90 citations
  4. 4Measurement of plasma cardiac troponin I concentration by use of a point-of-care analyzer in clinically normal horses and horses with experimentally induced cardiac disease2010 · 85 citations
  5. 5Troponin assays in the assessment of the equine myocardium2013 · 20 citations