Key result
Furosemide reduces EIPH scores in ~64% of treated horses without completely stopping pulmonary hemorrhage.
Why the study?
The repeatability of endoscopic observations of exercise-induced pulmonary hemorrhage and the efficacy of furosemide as prophylactic treatment in Thoroughbred racehorses were uncertain.
Does furosemide reduce exercise-induced pulmonary hemorrhage scores in Thoroughbred racehorses?
Population
56 Thoroughbred racehorses examined after consecutive breezes at or near maximum speed
Comparison
Furosemide treatment vs placebo (saline solution) and no treatment
Design
Observational study with repeated endoscopic assessments
Authors
Loading...
May reduce EIPH severity in racehorses; hypothesis-generating from Level 5 animal data and requires randomized confirmation before practice change.
Does furosemide reduce exercise-induced pulmonary hemorrhage scores in Thoroughbred racehorses?
In Thoroughbred racehorses, prophylactic furosemide reduces the severity of exercise-induced pulmonary hemorrhage but does not completely prevent it.
Pascoe et al. (1985) studied Exercise-induced pulmonary hemorrhage (EIPH) (n=56). Furosemide vs. Placebo (saline solution) and no treatment was evaluated on Reduction in EIPH score. Furosemide did not completely stop exercise-induced pulmonary hemorrhage but reduced the EIPH score in 64% (28 of 44) of the treated horses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: