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CNP/receptor expression findings in immune cells leave open immunomodulatory roles; mechanistic and clinical studies needed before relevance.
Background: C-type natriuretic peptide (CNP) was isolated from porcine brain and is a 22-amino acid peptide which belongs to the natriuretic peptide (NP) family. Even though this peptide shares structural similarity to other endogenous NPs including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) its receptor selectivity is different from other NPs. The present study was undertaken to investigate the expression of C-type natriuretic peptide (CNP) and its specifi c guanylyl cyclase (GC)-coupled receptor in the granulosa cells of the pig ovarian follicle.
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Kim Sung Zoo (2018) studied this question.
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