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February 1, 2000EndocrinologyOpen Access

B-Type Natriuretic Peptide Receptor Expression and Activity Are Hormonally Regulated in Rat Ovarian Cells1

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Population

Ovarian cells (granulosa and thecal-interstitial cells) obtained from immature female rats

Design

Preclinical

Authors

ANAlfred NoubaniRFRiaz FarookhiMcGill University Health CentreJGJolanta GutkowskaHeart Failure / Cardiomyopathy

Discussion

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Implication

May guide rodent models of ovarian CNP signaling; leaves open any direct implications for human fertility or endocrine disorders.

Structured PICO

P
Population
Ovarian cells (granulosa and thecal-interstitial cells) obtained from immature female rats
I
Intervention
Diethylstilbestrol (DES) or equine CG (eCG)
O
Outcome
Expression and activity of the natriuretic peptide system (CNP binding, NPR-B mRNA, cGMP release, CNP mRNA)surrogate

CNP and NPR-B are expressed in the rat ovary in a compartmentalized manner and their expression is responsive to hormonal treatments.

Cite This Study

Noubani et al. (2000) studied this question.

synapsesocial.com/papers/6a712baa26770c2b8de0f64dhttps://doi.org/10.1210/endo.141.2.7305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The atrial natriuretic peptide system in rat ovaries.1993 · 46 citations
  2. 2Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".1992 · 528 citations
  3. 3Cardiovascular and renal actions of C-type natriuretic peptide1992 · 139 citations
  4. 4Regulation of Endothelial Production of C-Type Natriuretic Peptide in Coculture With Vascular Smooth Muscle Cells1996 · 98 citations
  5. 5Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation.1994 · 132 citations